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Journal of Clinical Microbiology, December 2004, p. 5861-5865, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5861-5865.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

High Permissivity of Human HepG2 Hepatoma Cells for Influenza Viruses

Laurence Ollier, Anne Caramella, Valérie Giordanengo, and Jean-Claude Lefebvre*

INSERM U526-IFR 50, Laboratoire de Virologie, Faculté de Médecine, Nice, France

Received 18 December 2003/ Returned for modification 15 March 2004/ Accepted 25 June 2004

Human HepG2 hepatoma cells are highly permissive for influenza virus type A and type B, even without the addition of trypsin, and they exhibit a marked cytopathic effect. This property greatly facilitates the primary isolation of influenza viruses. Virus replication was significantly reduced by the plasmin(ogen)-specific inhibitor tranexamic acid, and this suggests a potential role played by the plasminogen/tissue plasminogen activator complex at the surface of HepG2 cells. This might represent a new approach for study of the interrelations of this complex with influenza viruses.

* Corresponding author. Mailing address: INSERM U526-Laboratoire de Virologie, Faculté de Médecine, avenue de Valombrose, 06107 Nice cedex 2, France. Phone: (33) 4 93377678. Fax: (33) 4 93815484. E-mail: lefebvre{at}unice.fr.

Journal of Clinical Microbiology, December 2004, p. 5861-5865, Vol. 42, No. 12
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.12.5861-5865.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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