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Journal of Clinical Microbiology, February 2004, p. 867-870, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.867-870.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Detection of the Candida Antigen Mannan in Cerebrospinal Fluid Specimens from Patients Suspected of Having Candida Meningitis

Frans M. Verduyn Lunel,1 Andreas Voss,2,3 Ed J. Kuijper,4 L. B. S. Gelinck,5 Peter M. Hoogerbrugge,6 K. L. Liem,7 Bart Jan Kullberg,3,8 and Paul E. Verweij2,3*

Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital,1 Departments of Medical Microbiology,2 Pediatric Oncology,6 Neonatal Intensive Care,7 General Internal Medicine,8 Nijmegen University Center for Infectious Diseases, University Medical Center Nijmegen, Nijmegen,3 Departments of Medical Microbiology ,4 Infectious Diseases, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands5

Received 16 June 2003/ Returned for modification 11 August 2003/ Accepted 8 November 2003

Cerebrospinal fluid samples from five patients from which Candida cells were cultured were tested for the presence of mannan. Samples from four patients categorized as having proven candidosis reacted positively. Samples from the remaining patient and from patients with other central nervous system infections were negative. Detection of mannan may be valuable in the diagnosis of Candida meningitis.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31-24-3614356. Fax: 31-24-3540216. E-mail: p.verweij{at}mmb.umcn.nl.

Journal of Clinical Microbiology, February 2004, p. 867-870, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.867-870.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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