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Journal of Clinical Microbiology, February 2004, p. 888-890, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.888-890.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Genetic Analysis of an Ambler Class A Extended-Spectrum Beta-Lactamase from Capnocytophaga ochracea

Anne Jolivet-Gougeon,1* Zohreh Tamanai-Shacoori,2 Laurent Desbordes,1 Nathalie Burggraeve,2 Michel Cormier,1 and Martine Bonnaure-Mallet2

Laboratoire de Microbiologie Pharmaceutique, UPRES-EA 1254, Université de Rennes 1, 35043 Rennes ,1 Equipe de Biologie Buccale, UPRES-EA 1256, UFR Odontologie, Université de Rennes 1, 35000 Rennes, France2

Received 24 June 2003/ Returned for modification 25 August 2003/ Accepted 2 October 2003

A beta-lactamase gene (cfxA3, 966 bp) was isolated from a beta-lactam-resistant Capnocytophaga ochracea clinical isolate and amplified using primers from the cfxA gene of Bacteroides vulgatus. The MICs of third-generation cephalosporins were much higher than those of the transconjugant Escherichia coli strain. The deduced protein sequence, by comparison with CfxA2 of Prevotella intermedia, had a Y239D substitution and possessed the characteristics of a class A, group 2e beta-lactamase.

* Corresponding author. Mailing address: Laboratoire de Microbiologie Pharmaceutique, UPRES-EA 1254, Université de Rennes 1, 2 avenue du Professeur Léon Bernard 35 043 Rennes, France. Phone: (33) 2 23 23 49 05. Fax: (33) 2 23 23 49 13. E-mail: anne.gougeon{at}univ-rennes1.fr.

Journal of Clinical Microbiology, February 2004, p. 888-890, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.888-890.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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