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Journal of Clinical Microbiology, February 2004, p. 895-898, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.895-898.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis

S. L. Sampson,1 M. Richardson,2 P. D. van Helden,2 and R. M. Warren2*

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115,1 MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Western Cape 7505, South Africa2

Received 5 September 2003/ Returned for modification 1 October 2003/ Accepted 23 October 2003

Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study provides the first description of an IS6110-mediated deletion event in truly isogenic strains. We also provide further support for the hypothesis that the region from Rv1754 to Rv1765 is a hot spot for IS6110 insertion and deletion events.

* Corresponding author. Mailing address: MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 27-21-9389482. Fax: 27-21-9317810. E-mail: RW1{at}SUN.AC.ZA.

Journal of Clinical Microbiology, February 2004, p. 895-898, Vol. 42, No. 2
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.2.895-898.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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