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Journal of Clinical Microbiology, March 2004, p. 1250-1253, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1250-1253.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Monoclonal Antibody Fragment Specific for Glycoprotein G in Herpes Simplex Virus Type 2 with Applications for Serotype-Specific Diagnosis

Francesca Bugli, Stefania Manzara, Riccardo Torelli, Rosalia Graffeo, Rosaria Santangelo, Paola Cattani,* and Giovanni Fadda

Istituto di Microbiologia, Università Cattolica del Sacro Cuore, 00168 Rome, Italy

Received 1 May 2003/ Returned for modification 19 August 2003/ Accepted 8 November 2003

A combinatorial library was used to select a human monoclonal antibody fragment (Fab) with high affinity for G glycoprotein in herpes simplex virus type 2 (HSV-2). Tests with 112 clinical specimens demonstrated successful discrimination between HSV-2 and HSV-1, showing the potential of Fab as a low-cost tool for HSV subtyping in clinical diagnosis.

* Corresponding author. Mailing address: Istituto di Microbiologia, Università Cattolica del Sacro Cuore, L. go F. Vito 1, 00168 Rome, Italy. Phone: 39-0630154336. Fax: 39-063051152. E-mail: pcattani{at}rm.unicatt.it.

Journal of Clinical Microbiology, March 2004, p. 1250-1253, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1250-1253.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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