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Journal of Clinical Microbiology, March 2004, p. 1265-1269, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1265-1269.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparative Analysis of agr Locus Diversification and Overall Genetic Variability among Bovine and Human Staphylococcus aureus Isolates

Unité de Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, F-37380 Nouzilly, France,¹ Erasmus MC, Rotterdam, The Netherlands²

Received 9 July 2003/ Returned for modification 23 September 2003/ Accepted 26 November 2003

The accessory gene regulator (agr) is a central system that controls the expression of Staphylococcus aureus virulence factors. In this study, the distribution of agr alleles, defined by agr restriction fragment length polymorphism within agr interference groups, among S. aureus isolates from bovine and human origin was measured with PCR-based techniques. Statistically highly significant associations of some agr alleles with the infection of a specific host were found. The genetic difference between the two S. aureus populations was further stressed after analysis of their genetic background by binary typing.

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