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Journal of Clinical Microbiology, March 2004, p. 1376-1378, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1376-1378.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Aspergillus fumigatus Empyema, Arthritis, and Calcaneal Osteomyelitis in a Lung Transplant Patient Successfully Treated with Posaconazole

Barbara Alexander Lodge,1* Elizabeth Dodds Ashley,1 Mark P. Steele,2 and John R. Perfect1*

Divisions of Infectious Diseases and International Health,1 Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina2

Received 3 September 2003/ Returned for modification 14 October 2003/ Accepted 30 October 2003

A 64-year-old male with Aspergillus fumigatus infection that had disseminated from the lung to the ankle and adjacent bone was treated successfully with posaconazole after therapy with itraconazole and amphotericin B lipid complex failed. Marked clinical improvement occurred within 6 weeks of initiation of posaconazole therapy; after 6 months, infection had resolved at all sites. The patient has had no recurrence of infection.

* Corresponding author. Mailing address for Barbara Alexander Lodge: Transplant Infectious Diseases Services, Clinical Mycology Laboratory, Box 3038, Duke University Medical Center, Durham, NC 27710. Phone: (919) 668-0789. Fax: (919) 684-8519. E-mail: alexa011{at}mc.duke.edu. Mailing address for John R. Perfect: Box 3353, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-6854. Fax: (919) 684-8902. E-mail: perfe001{at}mc.duke.edu.

Journal of Clinical Microbiology, March 2004, p. 1376-1378, Vol. 42, No. 3
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.3.1376-1378.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Rachwalski, E. J, Wieczorkiewicz, J. T, Scheetz, M. H (2008). Posaconazole: An Oral Triazole with an Extended Spectrum of Activity. The Annals of Pharmacotherapy 42: 1429-1438 [Abstract] [Full Text]  
  • Khan, S. A., Hasan, A. S., Capoor, M. R., Varshney, M. K., Trikha, V. (2007). Calcaneal Osteomyelitis Caused by Exophiala jeanselmei in an Immunocompetent Child. A Case Report. JBJS 89: 859-862 [Full Text]  


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