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Journal of Clinical Microbiology, April 2004, p. 1460-1465, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1460-1465.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Phenotypic and Genetic Characterization of a Unique Variant of Serogroup C ET-15 Meningococci (with the Antigenic Formula C:2a:P1.7,1) Causing Invasive Meningococcal Disease in Quebec, Canada

Raymond S. W. Tsang,1* Chao Ming Tsai,2 Peixuan Zhu,2,{dagger} Louise Ringuette,3 Manon Lorange,3 and Dennis K. S. Law1

CNS Infection Division, National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba,1 Laboratoire de santé publique du Québec, Institut national de santé publique du Québec, Ste-Anne-de-Bellevue, Québec, Canada,3 Division of Bacterial Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Washington, D.C.2

Received 5 November 2003/ Returned for modification 18 December 2003/ Accepted 22 December 2003

Serogroup C Neisseria meningitidis belonging to the electrophoretic type (ET) ET-15, a variant of ET-37, is endemic in Canada. Like other serogroup C ET-37 meningococci, the endemic ET-15 strains are usually found to carry the serotype and serosubtype antigens of 2a:P1.5,2. In 2001, a sudden increase in the number of cases of serogroup C meningococcal disease in Quebec, Canada, was caused by an antigenic variant of the ET-15 strain. This antigenic variant carries the unique serosubtype marker of P1.7,1. Strains of C:2a:P1.7,1 meningococci were not isolated in Canada in large numbers prior to 2001, and the characteristics of these meningococcal strains linked to an outbreak in Quebec, Canada, are described in the present study.

* Corresponding author. Mailing address: CNS Infection and Vaccine Preventable Bacterial Diseases Division, National Microbiology Laboratory, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-6020. Fax: (204) 789-2018. E-mail: rtsang{at}hc-sc.gc.ca.

{dagger} Present address: Creatv MicroTech, Inc., Potomac, MD 20854.

Journal of Clinical Microbiology, April 2004, p. 1460-1465, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1460-1465.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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