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Journal of Clinical Microbiology, April 2004, p. 1739-1741, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1739-1741.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans

Gannavaram Sreenivas,1 B. V. Subba Raju,1 Ruchi Singh,1 Angamuthu Selvapandiyan,2 Robert Duncan,2 Dwijen Sarkar,3 Hira L. Nakhasi,2 and Poonam Salotra1*

Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi,1 Indian Institute of Chemical Biology, Kolkata, India,3 Division of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland 208922

Received 20 July 2003/ Returned for modification 29 September 2003/ Accepted 5 January 2004

Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.

* Corresponding author. Mailing address: Institute of Pathology (ICMR), Safdarjung Hospital Campus, New Delhi 110029, India. Phone: 91-11-2616 6124. Fax: 91-11-2619 8401. E-mail: salotra{at}vsnl.com.

Journal of Clinical Microbiology, April 2004, p. 1739-1741, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1739-1741.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • KUMAR, R., BUMB, R. A., ANSARI, N. A., MEHTA, R. D., SALOTRA, P. (2007). CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA TROPICA IN BIKANER, INDIA: PARASITE IDENTIFICATION AND CHARACTERIZATION USING MOLECULAR AND IMMUNOLOGIC TOOLS. Am J Trop Med Hyg 76: 896-901 [Abstract] [Full Text]  


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