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Journal of Clinical Microbiology, April 2004, p. 1782-1784, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1782-1784.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Use of an Immunoglobulin G Avidity Test To Discriminate between Primary and Secondary Dengue Virus Infections

Vanda Akico Ueda Fick de Souza,1 Silvana Fernandes,1 Evaldo Stanislau Araújo,2 Adriana Fumie Tateno,1 Olímpia M. N. P. F. Oliveira,2 Renato dos Reis Oliveira,1 and Cláudio Sérgio Pannuti1*

Laboratório de Virologia (LIMHC-52), Instituto de Medicina Tropical de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo,1 Hospital Ana Costa, Santos, São Paulo, Brazil2

Received 15 August 2003/ Returned for modification 26 November 2003/ Accepted 25 December 2003

An enzyme-linked immunosorbent assay-based immunoglobulin G (IgG) antibody avidity test was evaluated by using sera from 57 patients with acute dengue infection. Overall, 55 of 57 patients were correctly classified (27 of 27 with primary dengue and 28 of 30 with secondary dengue). We conclude that the IgG avidity test can be useful for differentiating between acute, primary, and secondary dengue infections.

* Corresponding author. Mailing address: Laboratório de Virologia, Instituto de Medicina Tropical de São Paulo, Av. Eneas de Carvalho Aguiar, 470, CEP 05043-000 São Paulo (SP), Brazil.

Journal of Clinical Microbiology, April 2004, p. 1782-1784, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1782-1784.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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