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Journal of Clinical Microbiology, April 2004, p. 1843-1845, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1843-1845.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Linezolid-Resistant Enterococcus faecalis Isolated from a Cord Blood Transplant Recipient

Imad Dibo,1 Satish K. Pillai,2 Howard S. Gold,2 Maria R. Baer,1 Meir Wetzler,1 James L. Slack,1 Peggy A. Hazamy,1 Donna Ball,1 Chiu Bin Hsiao,1 Philip L. McCarthy Jr.,1 and Brahm H. Segal1*

Department of Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York,1 Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard School of Medicine, Boston, Massachusetts2

Received 2 December 2003/ Returned for modification 30 December 2003/ Accepted 5 January 2004

We report a linezolid-resistant Enterococcus faecalis infection in a cord blood stem cell transplant recipient previously treated with linezolid for bloodstream infections by vancomycin-resistant enterococci. Sequencing showed a G2576U mutation in the 23S rRNA gene. Because of the important niche of linezolid in cancer treatment, linezolid-resistant E. faecalis is noteworthy.

* Corresponding author. Mailing address: SUNY at Buffalo, Division of Infectious Diseases, Roswell Park Cancer Institute, Buffalo, NY 14263. Phone: (716) 845-5721. Fax: (716) 845-3423. E-mail: brahm.segal{at}roswellpark.org.

Journal of Clinical Microbiology, April 2004, p. 1843-1845, Vol. 42, No. 4
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.4.1843-1845.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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