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Journal of Clinical Microbiology, May 2004, p. 2161-2167, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2161-2167.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Hyperinvasive Neonatal Group B Streptococcus Has Arisen from a Bovine Ancestor

Naiel Bisharat,1* Derrick W. Crook,1 James Leigh,2 Rosalind M. Harding,3 Phil N. Ward,2 Tracey J. Coffey,2 Martin C. Maiden,3 Tim Peto,4 and Nicola Jones1

Nuffield Department of Clinical Laboratory Sciences,1 The Peter Medawar Building for Pathogen Research,3 The Academic Department of Microbiology and Infectious Disease, John Radcliffe Hospital, University of Oxford, Oxford,4 Institute for Animal Health, Compton Laboratory, Compton, Newbury, United Kingdom2

Received 22 December 2003/ Returned for modification 22 January 2004/ Accepted 3 February 2004

The genetic relatedness and evolutionary relationships between group B streptococcus (GBS) isolates from humans and those from bovines were investigated by phylogenetic analysis of multilocus sequence typing data. The collection of isolates consisted of 111 GBS isolates from cows with mastitis and a diverse global collection of GBS isolates from patients with invasive disease (n = 83) and carriers (n = 69). Cluster analysis showed that the majority of the bovine isolates (93%) grouped into one phylogenetic cluster. The human isolates showed greater diversity and clustered separately from the bovine population. However, the homogeneous human sequence type 17 (ST-17) complex, known to be significantly associated with invasive neonatal disease, was the only human lineage found to be clustered within the bovine population and was distinct from all the other human lineages. Split decomposition analysis revealed that the human isolate ST-17 complex, the major hyperinvasive neonatal clone, has recently arisen from a bovine lineage.

* Corresponding author. Mailing address: Nuffield Department of Clinical Laboratory Sciences, Microbiology, Level 7, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom. Phone: 44-1865-221226. Fax: 44-1865-764192. E-mail: nicola.jones{at}ndcls.ox.ac.uk.

Journal of Clinical Microbiology, May 2004, p. 2161-2167, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2161-2167.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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