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Journal of Clinical Microbiology, May 2004, p. 2186-2196, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2186-2196.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology of Foot-and-Mouth Disease Viruses in the Adamawa Province of Cameroon

B. M. de C. Bronsvoort,1* A. D. Radford,1 V. N. Tanya,2,{dagger} C. Nfon,2 R. P. Kitching,3,{ddagger} and K. L. Morgan1

Department of Veterinary Clinical Sciences, Leahurst Veterinary Teaching Hospital, University of Liverpool, Neston, Cheshire CH64 7TE,1 Institute of Animal Health, Pirbright, Woking, Surrey GU24 0NF, United Kingdom,3 Institute of Research in Agriculture for Development, Regional Centre of Wakwa, Ngaoundere, Cameroon2

Received 23 August 2003/ Returned for modification 11 November 2003/ Accepted 27 January 2004

Foot-and-mouth disease virus (FMDV) causes a highly contagious viral disease of even-toed ungulates and is one of the most important economic diseases of livestock. Most studies of FMDV are done in countries where control measures are being implemented. In contrast, in areas such as sub-Saharan Africa, where FMDV is endemic and new strains are likely to emerge, there are only sporadic submissions to the World Reference Laboratory, Pirbright, United Kingdom. This paper describes the molecular epidemiology of FMDV in the Adamawa province of Cameroon based on a population sample of cattle herds. Serotypes SAT2 and A were isolated in the cross-sectional study. SAT2 isolates were all similar, with phylogenetic distances of <6%, and were most closely related to published sequences of isolates from Eritrea and Saudi Arabia. Serotype A isolates were more variable, with phylogenetic distances of 0 to 11%, and were most closely related to historic isolates from Cameroon. Use of a population-based sample gives a representative sample of virus diversity and will improve our understanding of the evolution of FMDV and its epidemiology. A supplementary study of pigs passing through the railhead collection yard at Ngaoundere detected a serotype O virus. A third pilot longitudinal study monitored viral persistence in three cattle herds over 12 months, and serotype O and A viruses were recovered from a herd 12 months after it was first recorded as being infected with SAT2 virus. The pig type O isolate was not closely related to that recovered from the cattle, suggesting that the pigs had not introduced the O virus into the cattle herds.

* Corresponding author. Mailing address: Centre for Tropical Veterinary Medicine, The Royal (Dick) School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, United Kingdom. Phone: 44 131 650 7263. E-mail: mark.bronsvoort{at}ed.ac.uk.

{dagger} Present address: Institute of Agricultural Research for Development, Regional Centre of Bambui, Bamenda, Cameroon.

{ddagger} Present address: National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, Winnipeg, Manitoba, Canada.

Journal of Clinical Microbiology, May 2004, p. 2186-2196, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2186-2196.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cottam, E. M., Haydon, D. T., Paton, D. J., Gloster, J., Wilesmith, J. W., Ferris, N. P., Hutchings, G. H., King, D. P. (2006). Molecular Epidemiology of the Foot-and-Mouth Disease Virus Outbreak in the United Kingdom in 2001. J. Virol. 80: 11274-11282 [Abstract] [Full Text]  


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