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Human Papillomavirus Type 16 Viral Load Is Higher in Human Immunodeficiency Virus-Seropositive Women with High-Grade Squamous Intraepithelial Lesions Than in Those with Normal Cytology Smears

Jonas Lefevre,^1,2 Catherine Hankins,^3,4 Deborah Money,⁵ Anita Rachlis,⁶ Karina Pourreaux,⁴ The Canadian Women's HIV Study Group, and François Coutlée^1,2*

Laboratoire de Virologie Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal,¹ Département de Microbiologie et Immunologie, Université de Montréal,² Joint Departments of Epidemiology, Biostatistics and Occupational Health, McGill University,³ Direction de la Santé Publique de Montréal-Centre, Institut National de la Santé Publique du Québec, Montréal, Québec,⁴ Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia,⁵ Department of Epidemiology and Biostatistics, University of Toronto, Toronto, Ontario, Canada⁶

Received 10 November 2003/ Returned for modification 12 January 2004/ Accepted 26 January 2004

Human papillomavirus type 16 (HPV-16) viral load in cervicovaginal lavage samples collected from 66 human immunodeficiency virus-seropositive women was inversely correlated with blood CD4 count (P = 0.002). HPV-16 viral load was 81-fold higher in women with cervical smears suggestive of high-grade lesions (median, 4,425,883 copies/µg of DNA) than in women with normal smears (median, 54,576), controlling for age (P = 0.006).

Contributing members of The Canadian Women's HIV Study Group are listed in Acknowledgments.

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