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Journal of Clinical Microbiology, May 2004, p. 2212-2215, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2212-2215.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Human Papillomavirus Type 16 Viral Load Is Higher in Human Immunodeficiency Virus-Seropositive Women with High-Grade Squamous Intraepithelial Lesions Than in Those with Normal Cytology Smears

Jonas Lefevre,1,2 Catherine Hankins,3,4 Deborah Money,5 Anita Rachlis,6 Karina Pourreaux,4 The Canadian Women's HIV Study Group,{dagger} and François Coutlée1,2*

Laboratoire de Virologie Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal,1 Département de Microbiologie et Immunologie, Université de Montréal,2 Joint Departments of Epidemiology, Biostatistics and Occupational Health, McGill University,3 Direction de la Santé Publique de Montréal-Centre, Institut National de la Santé Publique du Québec, Montréal, Québec,4 Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia,5 Department of Epidemiology and Biostatistics, University of Toronto, Toronto, Ontario, Canada6

Received 10 November 2003/ Returned for modification 12 January 2004/ Accepted 26 January 2004

Human papillomavirus type 16 (HPV-16) viral load in cervicovaginal lavage samples collected from 66 human immunodeficiency virus-seropositive women was inversely correlated with blood CD4 count (P = 0.002). HPV-16 viral load was 81-fold higher in women with cervical smears suggestive of high-grade lesions (median, 4,425,883 copies/µg of DNA) than in women with normal smears (median, 54,576), controlling for age (P = 0.006).

* Corresponding author. Mailing address: Département de Microbiologie et Infectiologie, Hôpital Notre-Dame du Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke est, Montréal (Québec), H2L 4M1, Canada. Phone: (514) 890-8000, ext. 25162. Fax: (514) 412-7512. E-mail: francois.coutlee{at}ssss.gouv.qc.ca.

{dagger} Contributing members of The Canadian Women's HIV Study Group are listed in Acknowledgments.

Journal of Clinical Microbiology, May 2004, p. 2212-2215, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2212-2215.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Coutlee, F., Rouleau, D., Petignat, P., Ghattas, G., Kornegay, J. R., Schlag, P., Boyle, S., Hankins, C., Vezina, S., Cote, P., Macleod, J., Voyer, H., Forest, P., Walmsley, S., The Canadian Women's HIV Study Group, , Franco, E. (2006). Enhanced Detection and Typing of Human Papillomavirus (HPV) DNA in Anogenital Samples with PGMY Primers and the Linear Array HPV Genotyping Test.. J. Clin. Microbiol. 44: 1998-2006 [Abstract] [Full Text]  
  • Lillo, F. B., Uberti-Foppa, C. (2006). Human papillomavirus viral load: a possible marker for cervical disease in HIV-infected women. J Antimicrob Chemother 57: 810-814 [Abstract] [Full Text]  
  • Fontaine, J., Gravitt, P., Duh, L.-M., Lefevre, J., Pourreaux, K., Hankins, C., Coutlee, F., The Canadian Women's HIV Study Group, (2005). High Level of Correlation of Human Papillomavirus-16 DNA Viral Load Estimates Generated by Three Real-time PCR Assays Applied on Genital Specimens. Cancer Epidemiol. Biomarkers Prev. 14: 2200-2207 [Abstract] [Full Text]  


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