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Journal of Clinical Microbiology, May 2004, p. 2239-2240, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2239-2240.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Further Evaluation of a Rapid Diagnostic Test for Melioidosis in an Area of Endemicity

Menzies School of Health Research, Charles Darwin University and Northern Territory Clinical School, Flinders University,¹ Microbiology Laboratory, Pathology Department, Royal Darwin Hospital, Darwin, Northern Territory,³ University of Melbourne Faculty of Medicine, Melbourne, Australia²

Received 10 November 2003/ Returned for modification 6 January 2004/ Accepted 18 February 2004

Immunochromatographic test (ICT) kits for the rapid detection of immunoglobulin G (IgG) and IgM antibodies to Burkholderia pseudomallei were compared to the indirect hemagglutination (IHA) assay. In 138 culture-confirmed melioidosis cases, sensitivities were 80, 77, and 88% for IHA, ICT IgG, and ICT IgM, respectively. In a prospective study of 160 consecutive sera samples sent for melioidosis serology, respective specificities were 91, 90, and 69, positive predictive values were 41, 32, and 18, and negative predictive values were 99, 98, and 100%. ICT IgM kits are unreliable for diagnosis of melioidosis, but ICT IgG kits may be useful for diagnosing travelers presenting with possible melioidosis who return from regions where melioidosis is endemic.

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