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Journal of Clinical Microbiology, May 2004, p. 2321-2325, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2321-2325.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Meta-Analysis of BACTEC MGIT 960 and BACTEC 460 TB, with or without Solid Media, for Detection of Mycobacteria

HIV Outpatient Clinic, Center of Preventive Medicine, Verona,¹ Laboratory of Clinical Microbiology and Virology, Regional Mycobacteria Reference Center, San Bortolo Hospital, Vicenza,² Institute of Microbiology, University of Padua, Padua, Italy³

Received 2 September 2003/ Returned for modification 5 November 2003/ Accepted 7 January 2004

In a meta-analysis of 10 studies, the BACTEC 960/MGIT and BACTEC 460 systems showed a sensitivity and specificity in detecting mycobacteria (1,381 strains from 14,745 clinical specimens) of 81.5 and 99.6% and 85.8 and 99.9%, respectively. Combined with solid media, the sensitivity of the two systems increased to 87.7 and 89.7%, respectively.

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