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Journal of Clinical Microbiology, May 2004, p. 2345-2346, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2345-2346.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Invasive Pneumococcal Infection in a Healthy Infant Caused by Two Different Serotypes

Ana Lucia S. Sgambatti de Andrade,1* Fabiana Cristina Pimenta,1 Cristina Aparecida Borges Laval,2 João Guimarães de Andrade,1,3 Maria Luiza Guerra,4 and Maria Cristina C. Brandileone4

Institute of Tropical Pathology and Public Health, Federal University of Goiás,1 Epidemiological Surveillance Branch, Secretariat of Health of the Municipality of GoiÂnia,2 Tropical Diseases Hospital, GoiÂnia,3 Bacteriology Branch, Adolfo Lutz Institute, Secretariat of Health of the State of São Paulo, São Paulo, Brazil4

Received 8 November 2003/ Returned for modification 7 January 2004/ Accepted 26 January 2004

We present a case of invasive pneumococcal infection in a healthy 10-month-old infant from whom Streptococcus pneumoniae serotype 23F was isolated from the blood and serotype 23B was isolated from the cerebrospinal fluid. Both serotypes were penicillin nonsusceptible. Pulsed-field gel electrophoresis analysis demonstrated that the two serotypes had distinct DNA patterns, indicating that infection did not occur as a result of capsular transformation but as a result of a mixed infection with two distinct pneumococcal serotypes.

* Corresponding author. Mailing address: Instituto de Patologia Tropical e Saúde Pública, Rua Delenda R. Melo, S/N, Setor Universitário, 74605-050 Brazil. Phone and fax: 55-62-2027942. E-mail: ana{at}iptsp.ufg.br.

Journal of Clinical Microbiology, May 2004, p. 2345-2346, Vol. 42, No. 5
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.5.2345-2346.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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Copyright © 2004 by the American Society for Microbiology. All rights reserved.