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Journal of Clinical Microbiology, June 2004, p. 2366-2371, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2366-2371.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Nocardia arthritidis sp. nov., a New Pathogen Isolated from a Patient with Rheumatoid Arthritis in Japan

Akiko Kageyama,1,{dagger} Kimiaki Torikoe,2,{dagger} Masahiro Iwamoto,2 Jun-Ichi Masuyama,2 Yasuhiro Shibuya,3 Hitoaki Okazaki,2 Katsukiyo Yazawa,1 Seiji Minota,2 Reiner M. Kroppenstedt,4 and Yuzuru Mikami1*

Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba,1 Division of Rheumatology & Clinical Immunology,2 Department of Clinical Laboratory Medicine, Jichi Medical School, 3311-1, Yakushiji, Minamikawatchi, Tochigi, Japan,3 Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany4

Received 7 August 2003/ Returned for modification 8 November 2003/ Accepted 3 March 2004

Two different bacterial strains with different drug susceptibilities were isolated from the sputum and an inflammatory discharge from a swelling in the left thigh of a patient with rheumatoid arthritis. Both bacterial strains were provisionally assigned to the genus Nocardia on the basis of their morphological and chemotaxonomic characteristics and were further studied in order to establish their taxonomic status. One strain (IFM 10034) was identified as Nocardia farcinica on the basis of its physiological characteristics. The other strain, which was designated Nocardia sp. strain IFM 10035T, revealed a unique pattern of phenotypic properties that distinguished it from other representatives of established Nocardia species. Comparative 16S rRNA gene sequence studies of Nocardia sp. strain IFM 10035T also showed that the bacterium was closely related to the species Nocardia beijingensis. Determination of DNA-DNA relatedness, however, indicated that Nocardia sp. strain IFM 10035T could be delineated from N. beijingensis. The genotypic and phenotypic data combined indicated that the bacterium merits description as a new Nocardia species. The name proposed for the new species is Nocardia arthritidis sp. nov., the type strain being IFM 10035T (NBRC 100137T, JCM 12120T, DSM44731T). The present study suggests that Nocardia infections can be caused by multiple species of the bacterium.

* Corresponding author. Mailing address: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan. Phone: 81-43-226-2493. Fax: 81-43-226-2486. E-mail: mikami{at}faculty.chiba-u.jp.

{dagger} A. Kageyama and K. Torikoe contributed equally to this work.

Journal of Clinical Microbiology, June 2004, p. 2366-2371, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2366-2371.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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