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Journal of Clinical Microbiology, June 2004, p. 2847-2849, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2847-2849.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Subtype B Human Immunodeficiency Virus (HIV) Type 1 Mutant That Escapes Detection in a Fourth-Generation Immunoassay for HIV Infection

Catherine Gaudy,1 Alain Moreau,1 Sylvie Brunet,1 Jean-Michel Descamps,2 Pascale Deleplanque,2 Denys Brand,1 and Francis Barin1*

Laboratoire de Virologie, Equipe Associée 3250, Centre National de Référence du VIH, Centre Hospitalier Universitaire Bretonneau, Tours 37044,1 Centre Hospitalier, Niort, France2

Received 12 November 2003/ Accepted 21 February 2004

We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.

* Corresponding author. Mailing address: Laboratoire de Virologie, CHU Bretonneau, 37044 Tours Cedex, France. Phone: (33) 2 47 47 80 58. Fax: (33) 2 47 47 36 10. E-mail: fbarin{at}med.univ-tours.fr.

Journal of Clinical Microbiology, June 2004, p. 2847-2849, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2847-2849.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2004 by the American Society for Microbiology. All rights reserved.