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Journal of Clinical Microbiology, June 2004, p. 2850-2854, Vol. 42, No. 6
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.6.2850-2854.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Case of Epstein-Barr Virus (EBV)-Associated Thymic Carcinoid and Investigation of Existence of EBV-Infected Cells in Thymus and Thymic Tumors

Department of Clinical Laboratory Medicine, Faculty of Medicine, Kochi University School of Medicine, Nankoku, Kochi,¹ Departments of Internal Medicine,² Pathology, Shimonoseki-saiseikai Hospital, Shimonoseki,³ Department of Pathology, Shimonosekishi-ishikai Hospital, Shimonoseki,⁴ Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo,⁵ Department of Laboratory Sciences, Kumamoto University School of Health Sciences, Kumamoto,⁶ Department of Laboratory Sciences, Faculty of Health Sciences, Yamaguchi University School of Medicine, Yamaguchi, Japan⁷

Received 21 July 2003/ Returned for modification 16 February 2004/ Accepted 3 March 2004

We describe the first case of Epstein-Barr virus (EBV)-associated thymic carcinoid tumor found by in situ hybridization (ISH) on paraffin-embedded sections. ISH revealed that both tumor cells and infiltrated lymphocytes were EBV positive, while a few EBV-infected lymphocytes were detected in 2 of 11 thymuses and 1 of 11 thymomas.