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Journal of Clinical Microbiology, July 2004, p. 2898-2901, Vol. 42, No. 7
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.7.2898-2901.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Bacteremia in an Immunocompromised Patient Caused by a Commensal Neisseria meningitidis Strain Harboring the Capsule Null Locus (cnl)

National Reference Laboratory for Meningococci, Institute for Hygiene and Microbiology, University of Würzburg, Würzburg,¹ Institute of Microbiology and Immunology,² Department of Internal Medicine III, University of Ulm, Ulm, Germany³

Received 30 January 2004/ Returned for modification 18 March 2004/ Accepted 15 April 2004

We recently described the capsule null locus (cnl) of constitutively unencapsulated Neisseria meningitidis clonal lineages. cnl meningococci were recovered from healthy carriers at high frequency. We here report on the first case of invasive disease caused by cnl meningococci in a severely immunosuppressed patient with chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. The sequence type 845 strain was extensively typed and, furthermore, shown to be sensitive to serum bactericidal activity.

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