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Journal of Clinical Microbiology, July 2004, p. 3077-3082, Vol. 42, No. 7
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.7.3077-3082.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Widespread Dissemination in The Netherlands of the Epidemic Berlin Methicillin-Resistant Staphylococcus aureus Clone with Low-Level Resistance to Oxacillin

W. J. B. Wannet,* E. Spalburg, M. E. O. C. Heck, G. N. Pluister, R. J. L. Willems,{dagger} and A. J. de Neeling

National Institute of Public Health and the Environment, Bilthoven, The Netherlands

Received 5 November 2003/ Returned for modification 16 December 2003/ Accepted 15 April 2004

Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen and represents a growing public health burden due to the emergence and spread of epidemic strains, particularly within the hospital environment. An epidemic MRSA clone, with characteristic low-level resistance to oxacillin, emerged in the year 2000 and became endemic in the Netherlands. Multilocus sequence typing characterized the strain as sequence type 45, which was previously designated the Berlin epidemic MRSA clone. In 2 years, this strain has become the predominant MRSA clone in the Netherlands.

* Corresponding author. Mailing address: Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute of Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Phone: (31) 30 2742105. Fax: (31) 30 2744418. E-mail: wim.wannet{at}rivm.nl.

{dagger} Present address: Division of Acute Internal Medicine and Infectious Diseases, Department of Internal Medicine, University Medical Center, Utrecht, The Netherlands.

Journal of Clinical Microbiology, July 2004, p. 3077-3082, Vol. 42, No. 7
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.7.3077-3082.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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