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Influenza B Virus Victoria Group with a New Glycosylation Site Was Epidemic in Japan in the 2002-2003 Season

Department of Microbiology, Kobe Institute of Health, Chuo-ku, Kobe 650-0046,¹ Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Higashinari-ku, Osaka 537-0025,² Sakai City Institute of Public Health, Sakai 590-0953, Japan³

Received 4 December 2003/ Returned for modification 29 February 2004/ Accepted 12 April 2004

In the 2002-2003 season, influenza B virus Victoria strains were epidemic after a 6-year absence in Kobe City, Japan. They reacted poorly to the immune ferret sera prepared for use against the previous strain. An amino acid substitution in the HA1 region caused them to acquire an N-linked glycosylation site.

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