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Journal of Clinical Microbiology, July 2004, p. 3342-3345, Vol. 42, No. 7
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.7.3342-3345.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Differences in Clinical Manifestation of Streptococcus pneumoniae Infection Are Not Correlated with In Vitro Production and Release of the Virulence Factors Pneumolysin and Lipoteichoic and Teichoic Acids

Annette Spreer,1 Astrid Lis,1 Joachim Gerber,1 Ralf René Reinert,2 Helmut Eiffert,3 and Roland Nau1*

Departments of Neurology,1 Bacteriology, University of Göttingen, Göttingen,3 Institute of Medical Microbiology, National Reference Center for Streptococci, University of Aachen, Aachen, Germany2

Received 5 October 2003/ Returned for modification 25 November 2003/ Accepted 30 March 2004

Production and release of the pneumococcal virulence factors pneumolysin and lipoteichoic and teichoic acid in 75 clinical isolates were investigated. No difference was found between strains causing systemic infection or localized respiratory infection and isolates from asymptomatic carriers. This suggests that the presence of pneumolysin and lipoteichoic and teichoic acid is a necessary but not a sufficient condition for pneumococcal infection and development of invasive disease.

* Corresponding author. Mailing address: Dept. of Neurology, University Hospital, Robert-Koch-Str. 40, 37075 Göttingen, Germany. Phone: 49-551-398455. Fax: 49-551-398405. E-mail: rnau{at}gwdg.de.

Journal of Clinical Microbiology, July 2004, p. 3342-3345, Vol. 42, No. 7
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.7.3342-3345.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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