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Journal of Clinical Microbiology, August 2004, p. 3505-3512, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3505-3512.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Species of the Family Helicobacteraceae Detected in an Australian Sea Lion (Neophoca cinerea) with Chronic Gastritis

Andrew P. A. Oxley,1* Mark Powell,2 and David B. McKay3

School of Biological, Cellular, and Molecular Sciences, University of New England, Armidale, New South Wales 2351,1 Noosa Veterinary Surgery, Tewantin, Queensland 4565,2 Faculty of Science, University of the Sunshine Coast, Maroochydore District Capital, Queensland 4558, Australia3

Received 29 January 2004/ Returned for modification 5 March 2004/ Accepted 4 May 2004

We describe the first case of gastritis in a male Australian sea lion (Neophoca cinerea) in which members of the family Helicobacteraceae, particularly the genus Wolinella, were detected. The sea lion exhibited clinical signs of gastrointestinal disease, including abdominal pain, lack of appetite, and lethargy. Examination of one ileal and five gastric biopsy specimens collected over a 10-year period revealed persistent fibrosis and/or superficial focal erosion and ulceration of the lamina propria. Spiral-shaped organisms 5 to 12 µm long were observed in two of the gut biopsy specimens. While Helicobacter species were detected by PCR in one of the gastric biopsy specimens, Wolinella species were detected in four of the five gastric specimens, including those in which spiral-shaped organisms were observed. Comparisons of biopsy specimen ribosomal DNA sequences with those obtained from the feces of this animal, the gastric tissue of a clinically healthy individual, and the feces of several other cohoused sea lions and fur seals revealed a separate and possibly novel gastric Helicobacter species. A possibly novel Wolinella species, along with Wolinella succinogenes, was also identified. These findings highlight the pathogenic potential of other members of this family in the etiopathogenesis of gastric disease in these animals.

* Corresponding author. Mailing address: Faculty of Science, University of the Sunshine Coast, Maroochydore District Capital, Queensland 4558, Australia. Phone: 61 7 5459 4449. Fax: 61 7 5430 1276. E-mail: aoxley{at}usc.edu.au.

Journal of Clinical Microbiology, August 2004, p. 3505-3512, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3505-3512.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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