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Journal of Clinical Microbiology, August 2004, p. 3831-3833, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3831-3833.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vivo Acquisition of High-Level Resistance to Imipenem in Escherichia coli

Laurent Poirel, Claire Héritier, Colette Spicq, and Patrice Nordmann*

Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, South-Paris Medical School, University Paris XI, 94275 Le Kremlin-Bicêtre, France

Received 23 January 2004/ Returned for modification 24 February 2004/ Accepted 29 April 2004

Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.

* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 Rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France. Phone: 33 1 45 21 36 32. Fax: 33 1 45 21 63 40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr.

Journal of Clinical Microbiology, August 2004, p. 3831-3833, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3831-3833.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2004 by the American Society for Microbiology. All rights reserved.