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Journal of Clinical Microbiology, August 2004, p. 3837-3840, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3837-3840.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Multicenter Evaluation of a New Screening Test That Detects Clostridium difficile in Fecal Specimens

L. Zheng,1* S. F. Keller,1 D. M. Lyerly,1 R. J. Carman,1 C. W. Genheimer,1 C. A. Gleaves,2 S. J. Kohlhepp,2 S. Young,3 S. Perez,3 and K. Ye4

TechLab, Inc.,1 Department of Statistics, Virginia Tech, Blacksburg, Virginia,4 Providence Portland Medical Center, Portland, Oregon,2 TriCore Reference Laboratories, Albuquerque, New Mexico3

Received 11 February 2004/ Returned for modification 29 March 2004/ Accepted 30 April 2004

Clostridium difficile causes approximately 25% of nosocomial antibiotic-associated diarrheas and most cases of pseudomembranous colitis. We evaluated C. DIFF CHEK, a new screening test that detects glutamate dehydrogenase of C. difficile. Our results showed that this test was comparable to PCR in sensitivity and specificity and outperformed bacterial culture.

* Corresponding author. Mailing address: TechLab, Inc., 2001 Kraft Dr., Blacksburg, VA 24061. Phone: (540) 953-1664. Fax: (540) 953-1665. E-mail: zhengl{at}techlab.com.

Journal of Clinical Microbiology, August 2004, p. 3837-3840, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3837-3840.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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