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Journal of Clinical Microbiology, August 2004, p. 3850-3852, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3850-3852.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Use of Rapid and Conventional Testing Technologies for Human Immunodeficiency Virus Type 1 Serologic Screening in a Rural Kenyan Reference Laboratory

Ginamarie Foglia,1 G. Donald Royster IV,2 K. Monique Wasunna,3 Rukia Kibaya,3 Jennifer A. Malia,4 Eva K. Calero,4 Warren Sateren,4 Philip O. Renzullo,4 Merlin L. Robb,4 Deborah L. Birx,4 and Nelson L. Michael4*

U.S. Army Medical Research Unit—Kenya,1 Kenya Medical Research Institute, Nairobi, Kenya,3 Uniformed Services University School of Medicine, Bethesda, Maryland 20814,2 U.S. Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland 208504

Received 6 January 2004/ Returned for modification 10 April 2004/ Accepted 4 May 2004

We report a prospective comparison of human immunodeficiency virus type 1 testing by enzyme immunoassay and Western blot with four rapid tests of 486 subjects performed in rural Kenya. Rapid test sensitivity was 100%. Specificity ranged from 99.1 to 100%. Combined use of two Food and Drug Administration-approved rapid tests yielded a single false-positive result.

* Corresponding author. Mailing address: Division of Retrovirology, Walter Reed Army Institute of Research, 1600 East Gude Dr., Rockville, MD 20850. Phone: (301) 251-5051. Fax: (301) 762-7460. E-mail: nmichael{at}hivresearch.org.

Journal of Clinical Microbiology, August 2004, p. 3850-3852, Vol. 42, No. 8
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.8.3850-3852.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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