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Journal of Clinical Microbiology, September 2004, p. 4329-4331, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4329-4331.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Detection of Hepatitis A Virus RNA in Saliva

Vincent Mackiewicz, Elisabeth Dussaix, Marie-France Le Petitcorps, and Anne Marie Roque-Afonso*

Centre National de Référence pour les Virus à Transmission Entérique (HAV), Laboratoire de Virologie, Hôpital Paul Brousse, Villejuif, France

Received 19 March 2004/ Returned for modification 26 April 2004/ Accepted 2 May 2004

Hepatitis A virus (HAV) is shed in feces but also in saliva. HAV RNA was detected in saliva in five out of six acutely infected patients with HAV viremia. Serum and saliva sequences were identical. The simplicity of obtaining material allows the recommendation of the use of saliva for investigation of outbreaks.

* Corresponding author. Mailing address: Centre National de Référence pour les Virus à Transmission Entérique (HAV), Laboratoire de Virologie, Hôpital Paul Brousse, 94804 Villejuif, France. Phone: 33 1 45596956. Fax: 33 1 45593724. E-mail: anne-marie.roque{at}pbr.ap-hop-paris.fr.

Journal of Clinical Microbiology, September 2004, p. 4329-4331, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4329-4331.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 2004 by the American Society for Microbiology. All rights reserved.