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Journal of Clinical Microbiology, September 2004, p. 4358-4360, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4358-4360.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of the Sensititre YeastOne Colorimetric Antifungal Panel with a Modified NCCLS M38-A Method To Determine the Activity of Voriconazole against Clinical Isolates of Aspergillus spp.

Carmen Castro,1 M. Carmen Serrano,1 Bernardo Flores,1 Ana Espinel-Ingroff,2 and Estrella Martín-Mazuelos1*

Servicio de Microbiología, Hospital Universitario de Valme, Seville, Spain,1 Division of Infectious Diseases, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia2

Received 10 February 2004/ Returned for modification 5 April 2004/ Accepted 27 May 2004

The susceptibilities of 63 isolates of Aspergillus spp. to voriconazole were evaluated by a modified NCCLS M38-A method and the Sensititre YeastOne method. The overall agreement was 82.5%, ranging from 100% for Aspergillus niger and Aspergillus terreus to 62.5% for Aspergillus flavus. Discrepancies between the methods were due to higher Sensititre MICs. The Sensititre YeastOne method could have potential value for susceptibility testing of Aspergillus spp. to voriconazole.


* Corresponding author. Mailing address: H. U. Valme, Ctra. Cádiz s/n, Seville, Spain. Phone: 034-955015480. Fax: 034-955015481. E-mail: estrella.martin.sspa{at}juntadeandalucia.es.


Journal of Clinical Microbiology, September 2004, p. 4358-4360, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4358-4360.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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