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Journal of Clinical Microbiology, September 2004, p. 4370-4373, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4370-4373.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pathogenic Differences between North American and Latin American Strains of Histoplasma capsulatum var. capsulatum in Experimentally Infected Mice

Michelle M. Durkin,1 Patricia A. Connolly,1* Kian Karimi,2 Emerson Wheat,2 Carol Schnizlein-Bick,2 Stephen D. Allen,3 Katia Alves,4 Ram P. Tewari,5 and Elizabeth Keath6

Department of Medicine,2 Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, and,3 MiraVista Diagnostics/MiraBella Technologies, Indianapolis, Indiana,1 Instituto de Infectologia Emilio Ribas, Sao Paulo, Brazil,4 Department of Microbiology, Rutgers University, New Brunswick, New Jersey,5 Department of Biology, St. Louis University, St. Louis, Missouri6

Received 4 February 2004/ Returned for modification 23 March 2004/ Accepted 10 May 2004

Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.

* Corresponding author. Mailing address: MiraVista Diagnostics/MiraBella Technologies, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: pconnolly{at}miravistalabs.com.

Journal of Clinical Microbiology, September 2004, p. 4370-4373, Vol. 42, No. 9
0095-1137/04/$08.00+0     DOI: 10.1128/JCM.42.9.4370-4373.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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