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Journal of Clinical Microbiology, January 2005, p. 421-426, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.421-426.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Distribution of Major Genotypes among Methicillin-Resistant Staphylococcus aureus Clones in Asian Countries

Asian-Pacific Research Foundation for Infectious Diseases,¹ Division of Infectious Diseases,² Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea³

Received 1 July 2004/ Returned for modification 8 September 2004/ Accepted 13 September 2004

To investigate the evolutionary pattern and genotypic characteristics of methicillin-resistant Staphylococcus aureus (MRSA) strains in the Asian region, 74 MRSA strains isolated from 12 Asian countries were analyzed by multilocus sequence typing (MLST) and SCCmec typing. Overall, a total of 16 genotypes based on sequence type and SCCmec types were identified among MRSA strains from Asian countries. Data revealed two major genotypes of MRSA strains in Asia, with unique geographic distributions. By MLST analysis, all strains from Korea and Japan except one belonged to clonal complex 5 (CC5) while most MRSA isolates from other Asian countries belonged to CC239. SCCmec typing showed that most isolates from Korea and Japan were SSmec type II whereas SCCmec type III (or IIIA) was the most common type in strains from other Asian countries. Our data documented a unique geographic distribution and evolutionary pattern of MRSA clones in Asia.

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