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Journal of Clinical Microbiology, January 2005, p. 458-461, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.458-461.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Clonal Diversity of Metallo-ß-Lactamase-Possessing Pseudomonas aeruginosa in Geographically Diverse Regions of Japan

Department of Microbiology, Toho University School of Medicine, Tokyo,¹ Nara Medical University, Nara,² Kawasaki Medical School, Okayama,³ Saitama Medical School, Saitama,⁴ Hokkaido University Hospital, Sapporo,⁵ Tohoku University Graduate School of Medicine, Miyagi,⁶ Kanagawa Cardiovascular and Respiratory Diseases Center, Kanagawa, Japan⁷

Received 24 March 2004/ Returned for modification 30 April 2004/ Accepted 1 June 2004

The aim of this study was to determine the distribution of metallo-ß-lactamase-producing Pseudomonas aeruginosa in Japan and to investigate the molecular characteristics of resistance gene cassettes including the gene encoding this enzyme. A total of 594 nonduplicate strains of P. aeruginosa isolated from 60 hospitals throughout Japan in 2002 were evaluated. This study indicated that although the prevalence of imipenem-resistant P. aeruginosa has not increased compared to that found in previous studies, clonal distribution of the same strain across Japan is evident.

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