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Journal of Clinical Microbiology, January 2005, p. 464-467, Vol. 43, No. 1
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.1.464-467.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Cryptococcus neoformans Isolates from Transplant Recipients Are Not Selected for Resistance to Calcineurin Inhibitors by Current Immunosuppressive Regimens

Departments of Molecular Genetics and Microbiology,¹ Medicine,³ Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina,⁴ Division of Infectious Diseases, Pittsburgh Veterans Affairs Medical Center, Pittsburgh, Pennsylvania²

Received 28 June 2004/ Returned for modification 10 August 2004/ Accepted 15 September 2004

The immunosuppressants tacrolimus (FK506) and cyclosporine A inhibit calcineurin and have potent antifungal activity. In this study, 24% of Cryptococcus neoformans isolates from solid-organ transplant patients exhibited altered sensitivity to these drugs, which may have an impact on the infectious course but does not appear to be the consequence of immunosuppressive therapy.