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Journal of Clinical Microbiology, October 2005, p. 5074-5079, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5074-5079.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Characterization of Isolates of Salmonella enterica Serovar Typhimurium Displaying High-Level Fluoroquinolone Resistance in Japan

Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan,¹ Division of Clinical Microbiology, Saitama Institute of Public Health, Saitama, Japan,² Department of Bacteriology, Koto-Biken Medical Laboratories, Tsukuba, Japan,³ Department of Microbiology, Tokyo Metropolitan Institute of Public Health, Tokyo, Japan,⁴ Department of Microbiology, Kyorin University School of Health Sciences, Tokyo, Japan⁵

Received 26 April 2005/ Returned for modification 8 June 2005/ Accepted 14 July 2005

Strains of the multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium isolated in Japan were examined for high-level fluoroquinolone resistance. Since the first isolation in 2000 (described in reference 13), we have identified 12 human and 5 nonhuman isolates with high-level fluoroquinolone-resistance (ciprofloxacin MIC of 24 µg/ml or more). Most of these isolates shared some features including definitive phage type (DT12/193), resistance type (ACSSuTNCp; resistant to ampicillin, chloramphenicol, streptomycin, sulfonamides, tetracycline, nalidixic acid, and ciprofloxacin), and genotype on pulsed-field gel electrophoresis that were different from those of the MDR S. enterica Typhimurium DT104. Mutations in quinolone resistance-determining regions of gyrA and parC were also conserved in almost all of the isolates despite the absence of any apparent epidemiological relationships among cases. This suggests that a specific clonal group of the serovar Typhimurium with high levels of fluoroquinolone resistance is disseminating among animals and humans in Japan.

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