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Journal of Clinical Microbiology, October 2005, p. 5272-5274, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5272-5274.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Decay of Human Immunodeficiency Virus Type 1 Unintegrated DNA Containing Two Long Terminal Repeats in Infected Individuals after 3 to 8 Years of Sustained Control of Viremia

Jennifer L. McDermott,1,3 Isabella Martini,1,3 Davide Ferrari,1,3 Francesca Bertolotti,1 Claudio Giacomazzi,1,3 Giuseppe Murdaca,2 Francesco Puppo,2 Francesco Indiveri,2 and Oliviero E. Varnier1,3*

Sections of Microbiology,1 Internal Medicine and Clinical Immunology, School of Medicine, University of Genova,2 Diagnostic Microbiology of Infectious Diseases, Advanced Biotechnology Center, Genova, Italy3

Received 10 January 2005/ Returned for modification 22 April 2005/ Accepted 4 August 2005

Covert human immunodeficiency virus (HIV) replication was ongoing during the first 3 years of aviremia in 22 patients, as determined by detection of DNA containing two long terminal repeats (2LTR DNA). Although total HIV DNA was detected in 60 2LTR DNA-negative samples, the absence of 2LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication.

* Corresponding author. Mailing address: Section of Microbiology, University of Genova School of Medicine, Largo Rosanna Benzi, 10, 16132 Genova (EC), Italy. Phone: 39 010 353-7649. Fax: 39 010 353-7698. E-mail: oliviero.varnier{at}unige.it.

Journal of Clinical Microbiology, October 2005, p. 5272-5274, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5272-5274.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cara, A., Klotman, M. E. (2006). Retroviral E-DNA: persistence and gene expression in nondividing immune cells. J. Leukoc. Biol. 80: 1013-1017 [Abstract] [Full Text]  


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