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Journal of Clinical Microbiology, October 2005, p. 5275-5277, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5275-5277.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead

Leonardo A. Sechi,1,2* Maria Gazouli,3 John Ikonomopoulos,4 John C. Lukas,5 Antonio M. Scanu,6 Niyaz Ahmed,2,8 Giovanni Fadda,7 and Stefania Zanetti1

Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Università degli Studi di Sassari, Viale S. Pietro 43/B, 07100 Sassari, Italy,1 ISOGEM Collaborative Network on Other Tubercle Bacilli (The International Society for Genomic and Evolutionary Microbiology), Sassari, Italy,2 Department of Biology, School of Medicine, University of Athens, Athens, Greece,3 Agricultural University of Athens, Department of Anatomy-Physiology, Faculty of Animal Science, Athens, Greece,4 Department of Pharmacology, School of Medicine, Universidad del Pais Vasco, Leioa, Vizcaya, Spain,5 Clinica Chirurgica, Università degli Studi di Sassari, Viale S. Pietro, 07100 Sassari, Italy,6 Istituto di Microbiologia, Facoltà di Medicina e Chirurgia "Agostino Gemelli," Università Cattolica del Sacro Cuore, 00168 Rome, Italy,7 Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India8

Received 3 May 2005/ Returned for modification 11 July 2005/ Accepted 21 July 2005

The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD2/CARD15 gene (insC3020, G908R, and R702W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD2/CARD15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.

* Corresponding author. Mailing address: Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Università degli Studi di Sassari, Viale S. Pietro 43/B, 07100 Sassari, Italy. Phone: 39 079 228303. Fax: 39 079 212345. E-mail: sechila{at}uniss.it.

Journal of Clinical Microbiology, October 2005, p. 5275-5277, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5275-5277.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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