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Journal of Clinical Microbiology, October 2005, p. 5301-5304, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5301-5304.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Oligonucleotide Ligation Assay for Detection of Mutations Associated with Reverse Transcriptase and Protease Inhibitor Resistance in Non-B Subtypes and Recombinant Forms of Human Immunodeficiency Virus Type 1

Yolanda Vega, Lucía Pérez-Alvárez, Elena Delgado, Mercedes Muñoz, Gema Casado, Rocío Carmona, María Sierra, Elena Vázquez de Parga, Milagros Pinilla, Valentina García, Leandro Medrano, Gerardo Contreras, Miguel Thomson, and Rafael Nájera*

Área de Patogenia Viral, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain

Received 12 January 2005/ Returned for modification 22 April 2005/ Accepted 20 July 2005

The oligonucleotide ligation assay is a genotypic assay for the detection of resistance-associated mutations to reverse transcriptase and protease inhibitors in human immunodeficiency virus type 1 subtype B. This assay has been modified and developed for non-B subtypes and recombinant strains and has been evaluated with sequencing, resulting in a more sensitive assay than sequencing for non-B subtypes.

* Corresponding author. Mailing address: Viral Pathogenesis Department, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain. Phone: 34 91 8223910. Fax: 34 91 5097014. E-mail: rafael.najera{at}isciii.es.

Journal of Clinical Microbiology, October 2005, p. 5301-5304, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5301-5304.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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