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Journal of Clinical Microbiology, October 2005, p. 5312-5315, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5312-5315.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Use of Stored Serum from Uganda for Development and Evaluation of a Human Immunodeficiency Virus Type 1 Testing Algorithm Involving Multiple Rapid Immunoassays

Darrell E. Singer,1,2 Noah Kiwanuka,3 David Serwadda,4 Fred Nalugoda,3 Linda Hird,5 Jamie Bulken-Hoover,5 Godfrey Kigozi,3 Jennifer A. Malia,1,2 Eva K. Calero,1,2 Warren Sateren,1,2 Merlin L. Robb,2 Fred Wabwire-Mangen,4 Maria Wawer,6 Ronald H. Gray,7 Nelson Sewankambo,8 Deborah L. Birx,1,2 and Nelson L. Michael1,2*

Division of Retrovirology,1 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, Maryland 20850,2 Rakai Health Sciences Project, Kalisizo, Uganda,3 Institute of Public Health, College of Medicine, Makerere University, Kampala, Uganda,4 Uniformed Services University School of Medicine, Bethesda, Maryland 20814,5 Columbia University Mailman School of Public Health, New York City, New York 10032,6 Johns Hopkins University School of Public Health, Baltimore, Maryland 21215,7 College of Medicine, Makerere University, Kampala, Uganda8

Received 16 November 2004/ Returned for modification 22 April 2005/ Accepted 20 July 2005

We report the development and evaluation of a human immunodeficiency virus type 1 testing algorithm consisting of three rapid antibody detection tests. Stored serum samples from Uganda were utilized with a final algorithm sensitivity of 100% and a specificity of 98.9% (95% confidence interval, 98.6% to 99.3%).

* Corresponding author. Mailing address: Department of Molecu-lar Diagnostics & Pathogenesis, Division of Retrovirology, WalterReed Army Institute of Research, 1600 E. Gude Drive, Rockville, MD 20850. Phone: (301) 251-5051. Fax: (301) 762-7460. E-mail:nmichael{at}hivresearch.org.

Journal of Clinical Microbiology, October 2005, p. 5312-5315, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5312-5315.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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