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Journal of Clinical Microbiology, October 2005, p. 5344-5347, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5344-5347.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Outbreaks in Distinct Regions Due to a Single Klebsiella pneumoniae Clone Carrying a bla_VIM-1 Metallo-ß-Lactamase Gene

Department of Medical Microbiology, Medical School, University of Thessaly, Larissa,¹ Department of Microbiology, Hippokration General Hospital, Thessaloniki,² Department of Microbiology, School of Health Sciences, University of Athens, Athens, Greece³

Received 14 July 2005/ Accepted 19 July 2005

From December 2004 to March 2005, 27 Klebsiella pneumoniae clinical isolates that were positive by the imipenem-EDTA double-disk synergy test and that exhibited a single macrorestriction pattern were recovered in two distinct Greek hospitals. The isolates carried a transferable bla_VIM-1 metallo-ß-lactamase gene in a class 1 integron. Reverse transcriptase PCR showed that the gene was similarly expressed in low- and high-level carbapenem-resistant isolates, indicating the existence of additional resistance mechanisms. The clonal spread of VIM-1-producing K. pneumoniae strains in distinct regions where up to now bla_VIM-2 and bla_VIM-4 alleles were common is worrisome.

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