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Journal of Clinical Microbiology, October 2005, p. 5395-5396, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5395-5396.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Breakthrough Candida krusei Fungemia during Fluconazole Prophylaxis followed by Breakthrough Zygomycosis during Caspofungin Therapy in a Patient with Severe Aplastic Anemia Who Underwent Stem Cell Transplantation

Corrado Girmenia,* Maria Luisa Moleti, Alessandra Micozzi, Anna Paola Iori, Walter Barberi, Robin Foà, and Pietro Martino

Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Rome, Italy

Received 1 May 2005/ Returned for modification 17 June 2005/ Accepted 11 July 2005

We report a case of breakthrough invasive zygomycosis in a stem cell transplant recipient who was receiving caspofungin for treatment of a breakthrough Candida krusei fungemia that occurred during fluconazole prophylaxis. Also, patients receiving the echinocandin caspofungin remain at risk for pathogens, such as zygomycetes, that are intrinsically resistant to this agent.

* Corresponding author. Mailing address: Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Rome 00161, Italy. Phone: 39 06857951. Fax: 39 0644 241984. E-mail: girmenia{at}bce.uniroma1.it.

Journal of Clinical Microbiology, October 2005, p. 5395-5396, Vol. 43, No. 10
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.10.5395-5396.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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