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Journal of Clinical Microbiology, November 2005, p. 5547-5549, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5547-5549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Relationship between MIC and Minimum Sterol 14{alpha}-Demethylation-Inhibitory Concentration as a Factor in Evaluating Activities of Azoles against Various Fungal Species

Osamu Shimokawa,1* Masakazu Niimi,2 Ken Kikuchi,3 Mitsumasa Saito,4 Hideko Kajiwara,4 and Shin-ichi Yoshida4

Division of Oral Infectious Diseases and Immunology, Faculty of Dental Sciences,1 Department of Bacteriology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan,4 Department of Bioactive Molecules, National Institute of Infectious Diseases,2 Department of Infectious Diseases, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan3

Received 12 April 2005/ Returned for modification 16 July 2005/ Accepted 2 September 2005

The minimum growth-inhibitory concentrations (MICs) of azole antifungals were compared to their minimum sterol 14{alpha}-demethylation-inhibitory concentrations (MDICs) for clinical fungal isolates. The ascomycetous Candida yeasts tested were clearly divided into two groups: group I, consisting of C. albicans, C. tropicalis, and C. lusitaniae, had MICs that were much higher than the MDICs, whereas group II, comprising C. glabrata, C. parapsilosis, C. guilliermondii, and C. krusei, had MICs that were approximately equal to the MDICs. In the ascomycetous fungi Aspergillus fumigatus and Sporothrix schenckii, the MICs were indistinguishable from the MDICs. In the basidiomycetous fungi Cryptococcus (Filobasidiella) neoformans, C. curvatus, and Trichosporon asahii, the MICs and the MDICs were practically identical. These results support the notion that there are two distinct classes of fungi differing in their degree of tolerance to sterol 14{alpha}-demethylation deficiency. These findings have significant implications for both fungal physiology and antifungal chemotherapy.

* Corresponding author. Present address: Department of Microbiology, Nihon Pharmaceutical University, 10281 Komuro, Ina-cho, Kita-adachi-gun, Saitama 326-0806, Japan. Phone: 81-48-721-1155. Fax: 81-48-721-6718. E-mail: simo{at}nichiyaku.ac.jp.

Journal of Clinical Microbiology, November 2005, p. 5547-5549, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5547-5549.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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