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Journal of Clinical Microbiology, November 2005, p. 5819-5821, Vol. 43, No. 11
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.11.5819-5821.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Molecular Identification of Rhizomucor pusillus as a Cause of Sinus-Orbital Zygomycosis in a Patient with Acute Myelogenous Leukemia

Peter C. Iwen,^1* Alison G. Freifeld,² Lynne Sigler,³ and Stefano R. Tarantolo^2,

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska,¹ Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska,² University of Alberta Microfungus Collection and Herbarium, Devonian Botanic Garden, Edmonton, Alberta, Canada³

Received 12 July 2005/ Returned for modification 12 August 2005/ Accepted 27 August 2005

Sinus-orbital zygomycosis caused by Rhizomucor pusillus in a patient with acute myelogenous leukemia is described. Identification was achieved by sequencing of the internal transcribed spacer (ITS) regions of the rRNA gene and by expression of zygospores in mating. This report highlights the value of ITS sequencing as a diagnostic tool for the identification of R. pusillus and expands the understanding of infection types caused by this zygomycete.

Present address: Methodist Cancer Center, Omaha, Nebr.

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