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Journal of Clinical Microbiology, December 2005, p. 6120-6122, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6120-6122.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Frequency and Species Distribution of Gliotoxin-Producing Aspergillus Isolates Recovered from Patients at a Tertiary-Care Cancer Center

Russell E. Lewis,1,2* Nathan P. Wiederhold,3 Michail S. Lionakis,2 Randall A. Prince,1,2 and Dimitrios P. Kontoyiannis1,2

The University of Houston College of Pharmacy, Houston, Texas,1 The University of Texas M.D. Anderson Cancer Center, Houston, Texas,2 The University of Texas at Austin College of Pharmacy, Austin, Texas3

Received 23 July 2005/ Returned for modification 13 September 2005/ Accepted 4 October 2005

Aspergillus isolates (n = 103) collected from cancer patients were screened to determine the taxonomic distribution and quantity of gliotoxin production. Gliotoxin was detected in 93% of Aspergillus fumigatus, 75% of A. niger, 25% of A. terreus, and 4% of A. flavus cultures. Gliotoxin concentrations were highest in cultures of A. fumigatus.

* Corresponding author. Mailing address: University of Houston College of Pharmacy, Texas Medical Center Campus, 1441 Moursund St. #423, Houston, TX 77030. Phone: (713) 795-8326. Fax: (713) 795-8383. E-mail: rlewis{at}uh.edu.

Journal of Clinical Microbiology, December 2005, p. 6120-6122, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6120-6122.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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