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Journal of Clinical Microbiology, December 2005, p. 6130-6132, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6130-6132.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Molecular Evolution of Human Influenza A/H3N2 Virus in Asia and Europe from 2001 to 2003

X. Sherry Chi, Trentice V. Bolar, Ping Zhao, John S. Tam, Ruth Rappaport, and Sheau-Mei Cheng*

Applied Immunology and Microbiology Division, Wyeth Vaccines Research, Pearl River, New York 10965

Received 9 May 2005/ Returned for modification 15 August 2005/ Accepted 20 September 2005

Hemagglutinin sequences of 146 human influenza A/H3N2 strains identified in respiratory specimens from Asia and Europe during the 2001-2003 influenza seasons were analyzed by DNA sequencing. Our results suggest that four amino acid substitutions, L25I, H75Q, H155T, and Q156H, led to the antigenic conversion of the previously predominant A/Panama/2007/99-like strains to the more recent A/Fujian/411/2002-like strains.

* Corresponding author. Mailing address: Applied Immunology and Microbiology Division, Wyeth Vaccines Research, 401 N. Middletown Rd., Building 180, Pearl River, NY 10965. Phone: (845) 602-5115. Fax: (845) 602-5296. E-mail: chengsm{at}wyeth.com.

Journal of Clinical Microbiology, December 2005, p. 6130-6132, Vol. 43, No. 12
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.12.6130-6132.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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