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Comparison of the Avidity Index Method and the Serologic Testing Algorithm for Recent Human Immunodeficiency Virus (HIV) Seroconversion, Two Methods Using a Single Serum Sample for Identification of Recent HIV Infections

Center for Epidemiological Studies on HIV/AIDS of Catalonia (CEESCAT), Hospital Universitari Germans Trias i Pujol. Badalona, Spain,¹ Microbiology Service, Hospital Universitari Germans Trias i Pujol, Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona, Badalona, Spain,² Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy,³ Laboratory of Virology, Ospedale Amedeo di Savoia, Turin, Italy,⁴ Newborn Screening Quality Assurance Program, Centers for Disease Control and Prevention, Atlanta, Georgia⁵

Received 20 September 2005/ Returned for modification 22 September 2005/ Accepted 28 September 2005

A study was designed to compare an avidity index method to the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) for the detection of recent HIV infection. One hundred sixty HIV-positive sera were tested. Both techniques performed similarly in identifying recent infections, although STARHS tended to misclassify more individuals that had long-standing infection as being recently infected.

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