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Journal of Clinical Microbiology, February 2005, p. 635-640, Vol. 43, No. 2
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.2.635-640.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Isolation of Candida famata from a Patient with Acute Zonal Occult Outer Retinopathy

Luis Carrasco,^* Marta Ramos, Rebeca Galisteo, Diana Pisa, Manuel Fresno, and María Eugenia González

Centro de Biología Molecular (CSIC-UAM), Facultad de Ciencias, Universidad Autónoma, Cantoblanco, Madrid, Spain

Received 17 September 2004/ Accepted 18 September 2004

The etiology of a number of retinopathies, such as acute zonal occult outer retinopathy (AZOOR), remains undetermined. Candida famata was isolated from conjunctival exudates of a patient diagnosed with AZOOR. This yeast was very abundant, particularly in the more affected eye, while no other pathogens or fungal species were in evidence. Immunological tests revealed the presence of antigen-specific T lymphocytes by using C. famata as a challenge. Moreover, enzyme-linked immunosorbent assay analysis showed the presence of specific antibodies against this yeast in the patient's blood. Delayed hypersensitivity by use of a skin test was also positive. Finally, antifungal treatments led to improvements in several clinical symptoms, including funduscopic analysis. However, despite prolonged treatment with fluconazole and itraconazole, C. famata still appeared in the conjunctival exudates. The new antifungal voriconazole may represent a better choice for treatment.

Present address: Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.

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