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Journal of Clinical Microbiology, March 2005, p. 1372-1373, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1372-1373.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Confirming Positive Results of Nucleic Acid Amplification Tests (NAATs) for Chlamydia trachomatis: All NAATs Are Not Created Equal

J. Schachter,1* E. W. Hook,2 D. H. Martin,3 D. Willis,4 P. Fine,5 D. Fuller,6 J. Jordan,7 W. M. Janda,8 and M. Chernesky9

University of California, San Francisco, California,1 University of Alabama, Birmingham, Alabama,2 Louisiana State University Medical Center, New Orleans, Louisiana,3 Florida State Department of Health, Jacksonville, Florida,4 Planned Parenthood Foundation of Houston and Southeast Texas, Houston, Texas,5 Wishard Memorial Hospital, Indianapolis, Indiana,6 Magee-Womens Research Institute, Pittsburgh, Pennsylvania,7 University of Illinois, Chicago, Illinois,8 St. Joseph's Health Care Regional Virology and Chlamydiology Laboratory, Hamilton, Ontario, Canada9

Received 4 August 2004/ Returned for modification 7 October 2004/ Accepted 14 November 2004

The Centers for Disease Control and Prevention recommended confirming positive screening tests for Chlamydia trachomatis when positive predictive values are <90%. It is accepted that less sensitive tests (i.e., culture and immunoassays) should not be used to confirm the results of more sensitive nucleic acid amplification tests (NAATs). We show that the same principle applies when NAATs are used for confirmation.

* Corresponding author. Mailing address: Chlamydia Research Laboratory, Department of Laboratory Medicine, University of California, San Francisco, 1001 Potrero Ave., SFGH 3416, San Francisco, CA 94110. Phone: (415) 824-5115. Fax: (415) 821-8945. E-mail: jsch{at}itsa.ucsf.edu.

Journal of Clinical Microbiology, March 2005, p. 1372-1373, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1372-1373.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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