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Journal of Clinical Microbiology, March 2005, p. 1390-1394, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1390-1394.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genetic Diversity of Multidrug-Resistant Mycobacterium tuberculosis Isolates and Identification of 11 Novel rpoB Alleles in Taiwan

Ruwen Jou,1* Huang-Yau Chen,1 Chen-Yuan Chiang,2 Ming-Chih Yu,3 and Ih-Jen Su4

Reference Laboratory of Mycobacteriology, Center for Disease Control, Department of Health,1 Taipei Medical University-Municipal Wan Fang Hospital, Taipei,3 Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan, Republic of China,4 International Union Against Tuberculosis and Lung Disease, Paris, France2

Received 22 October 2004/ Returned for modification 28 October 2004/ Accepted 19 November 2004

Of 162 multidrug-resistant Mycobacterium tuberculosis isolates from Taiwan, 60.5% were found to belong to the Beijing family on the basis of spoligotyping results. IS6110 restriction fragment length polymorphism fingerprinting showed genetic diversity among the multidrug-resistant isolates. Furthermore, 90.1% of the multidrug-resistant isolates had mutations in the rpoB gene, and 11 novel alleles were recognized.

* Corresponding author. Mailing address: Reference Laboratory of Mycobacteriology, Center for Disease Control, Department of Health, Taiwan, 161 Kun-Yang St., Nan-Kang, Taipei 115, Taiwan. Phone: 886 2 26531370. Fax: 886 2 26531387. E-mail: rwj{at}cdc.gov.tw.

Journal of Clinical Microbiology, March 2005, p. 1390-1394, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1390-1394.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Huang, W.-L., Chen, H.-Y., Kuo, Y.-M., Jou, R. (2009). Performance Assessment of the GenoType MTBDRplus Test and DNA Sequencing in Detection of Multidrug-Resistant Mycobacterium tuberculosis. J. Clin. Microbiol. 47: 2520-2524 [Abstract] [Full Text]  


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