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Journal of Clinical Microbiology, March 2005, p. 1420-1425, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1420-1425.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Genetic Variability among Serotype G4 Italian Human Rotaviruses

S. Arista,1* G. M. Giammanco,1 S. De Grazia,1 C. Colomba,2 and V. Martella3

Dipartimento di Igiene e Microbiologia,1 Istituto di Malattie Infettive e Virologia, Università di Palermo, Palermo,2 Dipartimento di Sanità e Benessere degli Animali, Università di Bari, Bari, Italy3

Received 1 September 2004/ Returned for modification 18 October 2004/ Accepted 14 November 2004

A total of 254 serotype GH rotavirus strains were detected in Palermo, Italy, from 1985 to 2003. Out of 38 serotype G4 strains selected for genetic analysis, 14 were recognized by genotyping as type G9. Strains confirmed to belong to the G4 type showed temporal patterns of genetic evolution in their VP7 and VP4 gene sequences, and the latest Italian G4 strains were distantly related to the reference vaccinal ST3 strain.

* Corresponding author. Mailing address: Dipartimento di Igiene e Microbiologia, Università di Palermo, via del Vespro 133, 90127 Palermo, Italy. Phone: 39 0916553663. Fax: 39 0916553676. E-mail: arista{at}unipa.it.

Journal of Clinical Microbiology, March 2005, p. 1420-1425, Vol. 43, No. 3
0095-1137/05/$08.00+0     doi:10.1128/JCM.43.3.1420-1425.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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